PTGES (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 459 Sequence: atgcctgccc acagcctggt gatgagcagc ccggccctcc cggccttcct gctctgcagc acgctgctgg tcatcaagat gtacgtggtg gccatcatca cgggccaagt gaggctgcgg aagaaggcct ttgccaaccc cgaggatgcc ctgagacacg gaggccccca gtattgcagg agcgaccccg acgtggaacg ctgcctcagg gcccaccgga acgacatgga gaccatctac cccttccttt tcctgggctt cgtctactcc tttctgggtc ctaacccttt tgtcgcctgg atgcacttcc tggtcttcct cgtgggccgt gtggcacaca ccgtggccta cctggggaag ctgcgggcac ccatccgctc cgtgacctac accctggccc agctcccctg cgcctccatg gctctgcaga tcctctggga agcggcccgc Protein function: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:18682561, PubMed:10377395, PubMed:12672824, PubMed:12460774, PubMed:10869354, PubMed:12244105). Plays a key role in inflammation response, fever and pain. Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione- dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824). [The UniProt Consortium]