PRKCI (Vector pUC, Accession No. BC022016)

Length: 1764 Sequence: atgtcccaca cggtcgcagg cggcggcagc ggggaccatt cccaccaggt ccgggtgaaa gcctactacc gcggggatat catgataaca cattttgaac cttccatctc ctttgagggc ctttgcaatg aggttcgaga catgtgttct tttgacaacg aacagctctt caccatgaaa tggatagatg aggaaggaga cccgtgtaca gtatcatctc agttggagtt agaagaagcc tttagacttt atgagctaaa caaggattct gaactcttga ttcatgtgtt cccttgtgta ccagaacgtc ctgggatgcc ttgtccagga gaagataaat ccatctaccg tagaggtgca cgccgctgga gaaagcttta ttgtgccaat ggccacactt tccaagccaa gcgtttcaac aggcgtgctc actgtgccat ctgcacagac cgaatatggg gacttggacg ccaaggatat aagtgcatca actgcaaact cttggttcat aagaagtgcc ataaactcgt cacaattgaa tgtgggcggc attctttgcc acaggaacca gtgatgccca tggatcagtc atccatgcat tctgaccatg cacagacagt aattccatat aatccttcaa gtcatgagag tttggatcaa gttggtgaag aaaaagaggc aatgaacacc agggaaagtg gcaaagcttc atccagtcta ggtcttcagg attttgattt gctccgggta ataggaagag gaagttatgc caaagtactg ttggttcgat taaaaaaaac agatcgtatt tatgcaatga aagttgtgaa aaaagagctt gttaatgatg atgaggatat tgattgggta cagacagaga agcatgtgtt tgagcaggca tccaatcatc ctttccttgt tgggctgcat tcttgctttc agacagaaag cagattgttc tttgttatag agtatgtaaa tggaggagac ctaatgtttc atatgcagcg acaaagaaaa cttcctgaag aacatgccag attttactct gcagaaatca gtctagcatt aaattatctt catgagcgag ggataattta tagagatttg aaactggaca atgtattact ggactctgaa ggccacatta aactcactga ctacggcatg tgtaaggaag gattacggcc aggagataca accagcactt tctgtggtac tcctaattac attgctcctg aaattttaag aggagaagat tatggtttca gtgttgactg gtgggctctt ggagtgctca tgtttgagat gatggcagga aggtctccat ttgatattgt tgggagctcc gataaccctg accagaacac agaggattat ctcttccaag ttattttgga aaaacaaatt cgcataccac gttctatgtc tgtaaaagct gcaagtgttc tgaagagttt tcttaataag gaccctaagg aacgattggg ttgtcttcct caaacaggat ttgctgatat tcagggacac ccgttcttcc gaaatgttga ttgggatatg atggagcaaa aacaggtggt acctcccttt aaaccaaata tttctgggga atttggtttg gacaactttg attctcagtt tactaatgaa cgtgtccagc tcactccaga tgacgatgac attgtgagga agattgatca gtctgaattt gaaggttttg agtatatcaa tcctcttttg atgtctgcag aagaatgtgt Protein function: Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation. [The UniProt Consortium]