PPM1D (Vector pUC, Accession No. BC016480)

Length: 1818 Sequence: atggcggggc tgtactcgct gggagtgagc gtcttctccg accagggcgg gaggaagtac atggaggacg ttactcaaat cgttgtggag cccgaaccga cggctgaaga aaagccctcg ccgcggcggt cgctgtctca gccgttgcct ccgcggccgt cgccggccgc ccttcccggc ggcgaagtct cggggaaagg cccagcggtg gcagcccgag aggctcgcga ccctctcccg gacgccgggg cctcgccggc acctagccgc tgctgccgcc gccgttcctc cgtggccttt ttcgccgtgt gcgacgggca cggcgggcgg gaggcggcac agtttgcccg ggagcacttg tggggtttca tcaagaagca gaagggtttc acctcgtccg agccggctaa ggtttgcgct gccatccgca aaggctttct cgcttgtcac cttgccatgt ggaagaaact ggcggaatgg ccaaagacta tgacgggtct tcctagcaca tcagggacaa ctgccagtgt ggtcatcatt cggggcatga agatgtatgt agctcacgta ggtgactcag gggtggttct tggaattcag gatgacccga aggatgactt tgtcagagct gtggaggtga cacaggacca taagccagaa cttcccaagg aaagagaacg aatcgaagga cttggtggga gtgtaatgaa caagtctggg gtgaatcgtg tagtttggaa acgacctcga ctcactcaca atggacctgt tagaaggagc acagttattg accagattcc ttttctggca gtagcaagag cacttggtga tttgtggagc tatgatttct tcagtggtga atttgtggtg tcacctgaac cagacacaag tgtccacact cttgaccctc agaagcacaa gtatattata ttggggagtg atggactttg gaatatgatt ccaccacaag atgccatctc aatgtgccag gaccaagagg agaaaaaata cctgatgggt gagcatggac aatcttgtgc caaaatgctt gtgaatcgag cattgggccg ctggaggcag cgtatgctcc gagcagataa cactagtgcc atagtaatct gcatctctcc agaagtggac aatcagggaa actttaccaa tgaagatgag ttatacctga acctgactga cagcccttcc tataatagtc aagaaacctg tgtgatgact ccttccccat gttctacacc accagtcaag tcactggagg aggatccatg gccaagggtg aattctaagg accatatacc tgccctggtt cgtagcaatg ccttctcaga gaatttttta gaggtttcag ctgagatagc tcgagagaat gtccaaggtg tagtcatacc ctcaaaagat ccagaaccac ttgaagaaaa ttgcgctaaa gccctgactt taaggataca tgattctttg aataatagcc ttccaattgg ccttgtgcct actaattcaa caaacactgt catggaccaa aaaaatttga agatgtcaac tcctggccaa atgaaagccc aagaaattga aagaacccct ccaacaaact ttaaaaggac attagaagag tccaattctg gccccctgat gaagaagcat agacgaaatg gcttaagtcg aagtagtggt gctcagcctg caagtctccc cacaacctca cagcgaaaga actctgttaa actcaccatg cgacgcagac ttaggggcca gaagaaaatt ggaaatcctt tacttcatca acacaggaaa actgtttgtg Protein function: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity. [The UniProt Consortium]