PKD2L1 (Vector pUC, Accession No. BC025665)

Length: 2418 Sequence: atgaatgctg tgggaagtcc tgaggggcag gagctgcaaa agctggggag tggagcctgg gacaaccccg cctacagtgg tcccccttcc ccacacggga cgctgagagt ctgcaccatc tccagcacgg ggcctctcca gccccaaccc aagaagcctg aagatgaacc ccaggagacg gcatacagga cccaggtgtc cagctgctgc ctccatatct gtcaaggcat cagaggactt tggggaacaa ccctgactga gaacacagct gagaaccggg aactttatat caagaccacc ctgagggagc tgttggtata tattgtgttc ctggtggaca tctgtctact gacctatgga atgacaagct ccagtgctta ttactacacc aaagtgatgt ctgagctctt cttacatact ccatcagaca ctggagtctc ctttcaggcc atcagcagca tggcggactt ctgggatttt gcccagggcc cactactgga cagtttgtat tggaccaaat ggtacaacaa ccagagcctg ggccatggct cccactcctt catctactat gagaacatgc tgctgggggt tccgaggctg cggcagctaa aggtccgcaa tgactcctgt gtggtgcatg aagacttccg ggaggacatt ctgagctgct atgatgtcta ctctccagac aaagaagaac aactcccctt tgggcccttc aatggcacag cgtggacata ccactcgcag gatgagttgg ggggcttctc ccactggggc aggctcacaa gctacagcgg aggtggctac tacctggacc ttccaggatc ccgacagggt agtgcagagg ctctccgggc ccttcaggag gggctgtggc tggacagggg cactcgagtg gtgttcatcg acttctcagt ctacaatgcc aatatcaatc ttttctgtgt cctgaggctg gtggtggagt ttccagctac aggaggtgcc atcccatcct ggcaaatccg cacagtcaag ctgatccgct atgtcagcaa ctgggacttc tttatcgttg gctgtgaggt catcttctgc gtcttcatct tctactatgt ggtggaagag atcctggagc tccacattca ccggcttcgc tacctcagca gcatctggaa catactggac ctggtggtca tcttgctctc cattgtggct gtgggcttcc acatattccg aaccctcgag gtgaatcggc tcatggggaa gctcctgcag cagccaaaca cgtatgcaga ctttgagttc ctcgccttct ggcagacaca gtacaacaac atgaatgctg tcaacctctt cttcgcctgg atcaagatat tcaagtacat cagcttcaac aaaaccatga cccagctctc ctccacgctg gcccgctgtg ccaaggacat cctgggcttc gccgtcatgt tcttcattgt tttcttcgcc tatgcccaac tcggctacct gcttttcggg acccaagtgg aaaactttag cactttcatc aagtgcattt tcactcagtt ccggataatc ctcggggact ttgactacaa tgctatcgac aatgccaacc gcatcctggg ccctgcctac tttgtcacct atgtcttctt cgtcttcttc gtgctcctga acatgttcct ggccatcatc aatgacacat attcagaggt caaggaggag ctggctggac agaaggatga gctgcaactt tctgacctcc tgaaacaggg ctacaacaag accctactaa gactgcgtct gaggaaggag agggtttcgg atgtgcagaa ggtcctgcag ggtggggagc aggagatcca gtttgaggat ttcaccaaca ccttaaggga actgggacac gcagagcatg aaatcactga gctcacggcc accttcacca agtttgacag agatgggaat cgtattctgg atgagaagga acaggaaaaa atgcgacagg acctggagga agagagggtg gccctcaaca ctgagattga gaaactaggc cgatctattg tgagcagccc acaaggcaaa tcgggtccag aggctgccag agcaggaggc tgggtttcag gagaagaatt ctacatgctc acaaggagag ttctgcagct ggagactgtc ctggaaggag tagtgtccca gattgatgct gtaggctcaa agctgaaaat gctggagagg aaggggtggc tggctccctc cccaggcgtg aaggaacaag ctatttggaa gcacccgcag ccagccccag ctgtgacccc agacccctgg ggagtccagg gtgggcagga gagtgaggtt ccctataaaa gagaagagga agccttagag gagaggagac tctcccgtgg tgagattcca acgttgcaga Protein function: Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:23212381, PubMed:30004384). Pore-forming subunit of a calcium- permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336289). The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:19812697). The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:23212381). May play a role in the perception of carbonation taste. May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH. [The UniProt Consortium]