NPC1L1 (Vector pUC, Accession No. BC117178)

Length: 3999 Sequence: atggcggagg ccggcctgag gggctggctg ctgtgggccc tgctcctgcg cttggcccag agtgagcctt acacaaccat ccaccagcct ggctactgcg ccttctatga cgaatgtggg aagaacccag agctgtctgg aagcctcatg acactctcca acgtgtcctg cctgtccaac acgccggccc gcaagatcac aggtgatcac ctgatcctat tacagaagat ctgcccccgc ctctacaccg gccccaacac ccaagcctgc tgctccgcca agcagctggt atcactggaa gcgagtctgt cgatcaccaa ggccctcctc acccgctgcc cagcctgctc tgacaatttt gtgaacctgc actgccacaa cacgtgcagc cccaatcaga gcctcttcat caatgtgacc cgcgtggccc agctaggggc tggacaactc ccagctgtgg tggcctatga ggccttctac cagcatagct ttgccgagca gagctatgac tcctgcagcc gtgtgcgcgt ccctgcagct gccacgctgg ctgtgggcac catgtgtggc gtgtatggct ctgccctttg caatgcccag cgctggctca acttccaggg agacacaggc aatggtctgg ccccactgga catcaccttc cacctcttgg agcctggcca ggccgtgggg agtgggattc agcctctgaa tgagggggtt gcacgttgca atgagtccca aggtgacgac gtggcgacct gctcctgcca agactgtgct gcatcctgtc ctgccatagc ccgcccccag gccctcgact ccaccttcta cctgggccag atgccgggca gtctggtcct catcatcatc ctctgctctg tcttcgctgt ggtcaccatc ctgcttgtgg gattccgtgt ggcccccgcc agggacaaaa gcaagatggt ggaccccaag aagggcacca gcctctctga caagctcagc ttctccaccc acaccctcct tggccagttc ttccagggct ggggcacgtg ggtggcttcg tggcctctga ccatcttggt gctatctgtc atcccggtgg tggccttggc agcgggcctg gtctttacag aactcactac ggaccccgtg gagctgtggt cggcccccaa cagccaagcc cggagtgaga aagctttcca tgaccagcat ttcggcccct tcttccgaac caaccaggtg atcctgacgg ctcctaaccg gtccagctac aggtatgact ctctgctgct ggggcccaag aacttcagcg gaatcctgga cctggacttg ctgctggagc tgctagagct gcaggagagg ctgcggcacc tccaggtatg gtcgcccgaa gcacagcgca acatctccct gcaggacatc tgctacgccc ccctcaatcc ggacaatacc agtctctacg actgctgcat caacagcctc ctgcagtatt tccagaacaa ccgcacgctc ctgctgctca cagccaacca gacactgatg gggcagacct cccaagtcga ctggaaggac cattttctgt actgtgccaa tgccccgctc accttcaagg atggcacagc cctggccctg agctgcatgg ctgactacgg ggcccctgtc ttccccttcc ttgccattgg ggggtacaaa ggaaaggact attctgaggc agaggccctg atcatgacgt tctccctcaa caattaccct gccggggacc cccgtctggc ccaggccaag ctgtgggagg aggccttctt agaggaaatg cgagccttcc agcgtcggat ggctggcatg ttccaggtca cgttcatggc tgagcgctct ctggaagacg agatcaatcg caccacagct gaagacctgc ccatctttgc caccagctac attgtcatat tcctgtacat ctctctggcc ctgggcagct attccagctg gagccgagtg atggtggact ccaaggccac gctgggcctc ggcggggtgg ccgtggtcct gggagcagtc atggctgcca tgggcttctt ctcctacttg ggtatccgct cctccctggt catcctgcaa gtggttcctt tcctggtgct gtccgtgggg gctgataaca tcttcatctt tgttctcgag taccagaggc tgccccggag gcctggggag ccacgagagg tccacattgg gcgagcccta ggcagggtgg ctcccagcat gctgttgtgc agcctctctg aggccatctg cttcttccta ggggccctga cccccatgcc agctgtgcgg acctttgccc tgacctctgg ccttgcagtg atccttgact tcctcctgca gatgtcagcc tttgtggccc tgctctccct ggacagcaag aggcaggagg cctcccggtt ggacgtctgc tgctgtgtca agccccagga gctgcccccg cctggccagg gagaggggct cctgcttggc ttcttccaaa aggcttatgc ccccttcctg ctgcactgga tcactcgagg tgttgtgctg ctgctgtttc tcgccctgtt cggagtgagc ctctactcca tgtgccacat cagcgtggga ctggaccagg agctggccct gcccaaggac tcgtacctgc ttgactattt cctctttctg aaccgctact tcgaggtggg ggccccggtg tactttgtta ccaccttggg ctacaacttc tccagcgagg ctgggatgaa tgccatctgc tccagtgcag gctgcaacaa cttctccttc acccagaaga tccagtatgc cacagagttc cctgagcagt cttacctggc catccctgcc tcctcctggg tggatgactt cattgactgg ctgaccccgt cctcctgctg ccgcctttat atatctggcc ccaataagga caagttctgc ccctcgaccg tcaactctct gaactgccta aagaactgca tgagcatcac gatgggctct gtgaggccct cggtggagca gttccataag tatcttccct ggttcctgaa cgaccggccc aacatcaaat gtcccaaagg cggcctggca gcatacagca cctctgtgaa cttgacttca gatggccagg ttttagcctc caggttcatg gcctatcaca agcccctgaa aaactcacag gattacacag aagctctgcg ggcagctcga gagctggcag ccaacatcac tgctgacctg cggaaagtgc ctggaacaga cccggctttt gaggtcttcc cctacacgat caccaatgtg ttttatgagc agtacctgac catcctccct gaggggctct tcatgctcag cctctgcctt gtgcccacct tcgctgtctc ctgcctcctg ctgggcctgg acctgcgctc cggcctcctc aacctgctct ccattgtcat gatcctcgtg gacactgtcg gcttcatggc cctgtggggc atcagttaca atgctgtgtc cctcatcaac ctggtctcgg cggtgggcat gtctgtggag tttgtgtccc acattacccg ctcctttgcc atcagcacca agcccacctg gctggagagg gccaaagagg ccaccatctc tatgggaagt gcggtgtttg caggtgtggc catgaccaac ctgcctggca tccttgtcct gggcctcgcc aaggcccagc tcattcagat cttcttcttc cgcctcaacc tcctgatcac tctgctgggc ctgctgcatg gcttggtctt cctgcccgtc atcctcagct atgtggggcc tgacgtcaac ccggctctgg cactggagca gaagcgggct gaggaggcgg tggcagcagt catggtggcc tcttgcccaa atcacccctc ccgagtctcc acagctgaca acatctatgt caaccacagc tttgaaggtt ctatcaaagg tgctggtgcc atcagcaact tcttgcccaa caatgggcgg Protein function: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. [The UniProt Consortium]