KCTD13 (Vector pUC, Accession No. BC036228)

Length: 990 Sequence: atgtcggcgg aggcctcggg cccggctgcc gccgcggccc cgtccctgga agcccccaag ccctcgggtc tcgagcctgg ccccgccgcc tacggtctca agccgctgac cccgaacagc aaatacgtga agctgaacgt gggcggctcg ttgcactaca ccacgctgcg caccctcacg ggacaggaca ccatgctcaa agccatgttc agcggccgcg tggaggtgct gaccgatgcc ggaggttggg tgctgattga ccggagcggc cgtcactttg gtacaatcct caattacctg cgggatgggt ctgtgccact gccggagagt acgagagaac tgggggagct gctgggcgaa gcacgctact acctggtgca gggcctgatt gaggactgcc agctggcgct gcagcaaaaa agggagacgc tgtccccgct gtgcctcatc cccatggtga catctccccg ggaggagcag cagctcctgg ccagcacctc caagcccgtg gtgaagctcc tgcacaaccg cagtaacaac aagtactcct acaccagcac ttcagatgac aacctactta agaacatcga gctgttcgac aagctggccc tgcgcttcca cgggcggcta ctcttcctca aggatgtcct gggggacgag atctgttgct ggtctttcta cgggcagggc cgcaaaatcg ccgaggtgtg ctgcacctcc attgtctatg ctacggagaa gaagcagacc aaggtggaat ttccagaggc ccggatcttc gaggagaccc tgaacatcct catctacgag actccccggg gcccagaccc agccctcctg gaggccacag ggggagcagc tggagctggt ggggctggcc gcggggagga tgaagagaac cgagagcacc gtgtccgcag gatccatgtc cggcgccata tcacccacga cgagcgtcct catggccaac aaattgtctt Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission. [The UniProt Consortium]