HTR1B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1173 Sequence: ATGGAGGAAC CGGGTGCTCA GTGCGCTCCA CCGCCGCCCG CGGGCTCCGA GACCTGGGTT CCTCAAGCCA ACTTATCCTC TGCTCCCTCC CAAAACTGCA GCGCCAAGGA CTACATTTAC CAGGACTCCA TCTCCCTACC CTGGAAAGTA CTGCTGGTTA TGCTATTGGC GCTCATCACC TTGGCCACCA CGCTCTCCAA TGCCTTTGTG ATTGCCACAG TGTACCGGAC CCGGAAACTG CACACCCCGG CTAACTACCT GATCGCCTCT CTGGCGGTCA CCGACCTGCT TGTGTCCATC CTGGTGATGC CCATCAGCAC CATGTACACT GTCACCGGCC GCTGGACACT GGGCCAGGTG GTCTGTGACT TCTGGCTGTC GTCGGACATC ACTTGTTGCA CTGCCTCCAT CCTGCACCTC TGTGTCATCG CCCTGGACCG CTACTGGGCC ATCACGGACG CCGTGGAGTA CTCAGCTAAA AGGACTCCCA AGAGGGCGGC GGTCATGATC GCGCTGGTGT GGGTCTTCTC CATCTCTATC TCGCTGCCGC CCTTCTTCTG GCGTCAGGCT AAGGCCGAAG AGGAGGTGTC GGAATGCGTG GTGAACACCG ACCACATCCT CTACACGGTC TACTCCACGG TGGGTGCTTT CTACTTCCCC ACCCTGCTCC TCATCGCCCT CTATGGCCGC ATCTACGTAG AAGCCCGCTC CCGGATTTTG AAACAGACGC CCAACAGGAC CGGCAAGCGC TTGACCCGAG CCCAGCTGAT AACCGACTCC CCCGGGTCCA CGTCCTCGGT CACCTCTATT AACTCGCGGG TTCCCGACGT GCCCAGCGAA TCCGGATCTC CTGTGTATGT GAACCAAGTC AAAGTGCGAG TCTCCGACGC CCTGCTGGAA AAGAAGAAAC TCATGGCCGC TAGGGAGCGC AAAGCCACCA AGACCCTAGG GATCATTTTG GGAGCCTTTA TTGTGTGTTG GCTACCCTTC TTCATCATCT CCCTAGTGAT GCCTATCTGC AAAGATGCCT GCTGGTTCCA CCTAGCCATC TTTGACTTCT TCACATGGCT GGGCTATCTC AACTCCCTCA TCAACCCCAT AATCTATACC ATGTCCAATG AGGACTTTAA ACAAGCATTC CATAAACTGA TACGTTTTAA GTGCACAAGT Protein function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. [The UniProt Consortium]