HIST3H2A (Vector pUC, Accession No. BC001193)

Length: 393 Sequence: atgtccggtc gtggtaagca gggtggcaag gcgcgcgcca aggctaagtc gcgctcgtcg cgcgcggggc tgcagttccc cgtgggccgc gtgcaccggt tgctccgcaa gggcaactat tcggagcgcg tgggcgccgg cgccccggtc tatctggccg cggtgctcga gtacttgact gccgagatcc tggagcttgc cggcaacgcg gcgcgcgaca acaagaagac gcgcatcatc ccgcgccacc tgcagctggc catccgcaac gacgaggagc tcaacaagct gctgggccgc gtgaccatcg cgcagggtgg cgtcctgccc aacatccagg ccgtactgct gcccaagaag acggagagcc accacaaggc caagggcaag Protein function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [The UniProt Consortium]