GSDMD (Vector pENTR223.1, Accession No. BC008904)

Length: 1455 Sequence: atggggtcgg cctttgagcg ggtagtccgg agagtggtcc aggagctgga ccatggtggg gagttcatcc ctgtgaccag cctgcagagc tccactggct tccagcccta ctgcctggtg gttaggaagc cctcaagctc atggttctgg aaaccccgtt ataagtgtgt caacctgtct atcaaggaca tcctggagcc ggatgccgcg gaaccagacg tgcagcgtgg caggagcttc cacttctacg atgccatgga tgggcagata cagggcagcg tggagctggc agccccagga caggcaaaga tcgcaggcgg ggccgcggtg tctgacagct ccagcacctc aatgaatgtg tactcgctga gtgtggaccc taacacctgg cagactctgc tccatgagag gcacctgcgg cagccagaac acaaagtcct gcagcagctg cgcagccgcg gggacaacgt gtacgtggtg actgaggtgc tacagacaca gaaggaggtg gaagtcacgc gcacccacaa gcgggagggc tcgggccggt tttccctgcc cggagccacg tgcttgcagg gtgagggcca gggccatctg agccagaaga agacggtcac catcccctca ggcagcaccc tcgcattccg ggtggcccag ctggttattg actctgactt ggacgtcctt ctcttcccgg ataagaagca gaggaccttc cagccacccg cgacaggcca caagcgttcc acgagcgaag gcgcctggcc acagctgccc tctggcctct ccatgatgag gtgcctccac aacttcctga cagatggggt ccctgcggag ggggcgttca ctgaagactt ccagggccta cgggcagagg tggagaccat ctccaaggaa ctggagcttt tggacagaga gctgtgccag ctgctgctgg agggcctgga gggggtgctg cgggaccagc tggccctgcg agccttggag gaggcgctgg agcagggcca gagccttggg ccggtggagc ccctggacgg tccagcaggt gctgtcctgg agtgcctggt gttgtcctcc ggaatgctgg tgccggaact cgctatccct gttgtctacc tgctgggggc actgaccatg ctgagtgaaa cgcagcacaa gctgctggcg gaggcgctgg agtcgcagac cctgttgggg ccgctcgagc tggtgggcag cctcttggag cagagtgccc cgtggcagga gcgcagcacc atgtccctgc cccccgggct cctggggaac agctggggcg aaggagcacc ggcctgggtc ttgctggacg agtgtggcct agagctgggg gaggacactc cccacgtgtg ctgggagccg caggcccagg gccgcatgtg tgcactctac gcctccctgg cactgctatc aggactgagc caggagcccc Protein function: [Gasdermin-D]: Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216). [The UniProt Consortium]