GABARAPL2 (Vector pENTR223.1, Accession No. BC029601)

Length: 354 Sequence: atgaagtgga tgttcaagga ggaccactcg ctggaacaca gatgcgtgga gtccgcgaag attcgagcga aatatcccga cagggttccg gtgattgtgg aaaaggtctc aggctctcag attgttgaca ttgacaaacg gaagtacttg gtcccatctg atatcactgt ggctcagttc atgtggatca tcaggaaaag gatccagctt ccttctgaaa aggcgatctt cctgtttgtg gataagacag tcccacagtc cagcctaact atgggacagc tttacgagaa ggaaaaagat gaagatggat tcttatatgt ggcctacagc ggagagaaca cttttggctt Protein function: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295). [The UniProt Consortium]