GABARAPL1 (Vector pENTR223.1, Accession No. BC009309)

Length: 354 Sequence: atgaagttcc agtacaagga ggaccatccc tttgagtatc ggaaaaagga aggagaaaag atccggaaga aatatccgga cagggtcccc gtgattgtag agaaggctcc aaaagccagg gtgcctgatc tggacaagag gaagtaccta gtgccctctg accttactgt tggccagttc tacttcttaa tccggaagag aatccacctg agacctgagg acgccttatt cttctttgtc aacaacacca tccctcccac cagtgctacc atgggccaac tgtatgagga caatcatgag gaagactatt ttctgtatgt ggcctacagt gatgagagtg tctatgggaa Protein function: Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). [The UniProt Consortium]