AP4M1 (Vector pUC, Accession No. BC018705)

Length: 1362 Sequence: atgatttccc aattcttcat tctgtcctcc aagggggacc cgctcatcta caaagacttc cgcggggaca gtggcggccg ggatgtggcc gagctcttct accggaagct gacgggactg ccaggagacg agtccccggt tgtcatgcat caccatggcc gtcatttcat tcacatcaga cacagcggcc tctatttggt ggtcacaact tcagaaaacg tttctccctt cagcctccta gaactgctct ccaggttggc cacccttctg ggcgattact gtggctccct gggcgagggg accatctccc gcaatgtggc tctggtatac gaactcctgg atgaagtgct ggactatggc tatgtacaga ccacatccac ggagatgctg aggaatttca tccagacgga agctgtggtc agcaagccct tcagcctctt tgacctcagc agcgttggct tgtttggggc tgagacacaa cagagcaaag tggcccccag cagtgcagcc agccgccccg tcctgtccag tcgctctgac cagagccaaa agaatgaagt ttttttggat gtggtcgaga gattgtctgt actgatagca tctaatggat ccctgctgaa ggtggatgtg cagggagaga ttcggctcaa gagcttcctt cctagcggct ctgagatgcg cattggcttg acggaagagt tttgtgtggg gaagtcagag ctgagaggtt atgggccagg aatccgggtc gatgaagtct cgtttcacag ctctgtgaat ctggacgaat ttgagtctca tcgaatcctc cgcttgcaac cacctcaggg cgagctgact gtgatgcggt accaactctc cgatgacctc ccctcaccgc tccccttccg gctcttcccc tctgtgcagt gggaccgagg ctcaggccgg ctccaggttt atctaaagtt gcgatgtgac ctgctctcaa agagccaagc cctcaatgtc aggctgcacc tccccctgcc tcgaggggtg gtcagcctgt ctcaggagct gagcagccca gagcagaagg ctgagctggc agagggagcc cttcgctggg acctgcctcg ggtgcaagga ggctctcaac tctcaggcct tttccagatg gacgtcccag ggcccccagg acctcccagc catgggctct ccacctcggc ctctcctctg gggctgggcc ctgccagtct ctccttcgag cttccccggc acacgtgctc tggcctccag gtccgattcc tcaggctggc cttcaggcca tgcggcaatg ccaaccccca caagtgggtg cgacacctaa gccacagcga cgcctatgtc attcggatct Protein function: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal. [The UniProt Consortium]