ANKRD27 (Vector pUC, Accession No. BC050529)

Length: 3153 Sequence: atggctctgt atgatgaaga cctcctgaaa aatcctttct atctggctct gcaaaagtgc cgccctgact tgtgcagcaa agtggcccaa atccatggca ttgtcttagt accctgcaaa ggaagcctgt cgagcagcat ccagtctact tgtcagtttg agtcctacat tttgatacct gtggaagagc attttcagac cttaaatgga aaggatgtct ttattcaagg gaacaggatt aaattaggag ctggttttgc ctgtcttctc tcagtgccca ttctctttga agaaactttc tacaatgaaa aagaagagag tttcagcatc ctgtgtatag cccatccttt ggaaaagaga gagagttcag aagagccttt ggcaccctca gatccctttt ccctgaaaac cattgaagat gtgagagagt tcttgggaag acactccgag cgatttgaca ggaacatcgc ctctttccat cgaacattcc gagaatgcga gagaaagagc ctccgtcacc acatagactc agcgaatgct ctctacacca aatgcctcca gcagcttctg agggactctc acctgaaaat gctcgccaag caggaggccc agatgaacct gatgaagcag gcagtggaga tatacgtcca tcatgaaatt tacaacctga tctttaaata cgtggggacc atggaggcaa gtgaggatgc ggcctttaac aaaatcacaa gaagccttca agatcttcag cagaaagata ttggtgtgaa accggagttc agctttaaca tacctcgtgc caaaagagag ctggctcagc tgaacaaatg cacctcccca cagcagaagc ttgtctgctt gcgaaaagtg gtgcagctca ttacacagtc tccaagccag agagtgaacc tggagaccat gtgtgctgat gatctgctat cagtcctgtt atacttgctt gtgaaaacgg agatccctaa ttggatggca aatttgagtt acatcaaaaa cttcaggttt agcagcttgg caaaggatga actgggatac tgcctgacct cattcgaagc tgccattgaa tatattcggc aaggaagcct ctctgctaaa ccccctgagt ctgagggatt tggagacagg ctgttcctta agcagagaat gagcttactc tctcagatga cttcgtctcc caccgactgc ctgtttaagc acattgcatc aggtaaccag aaagaagtgg agagacttct gagccaagag gaccatgata aagataccgt ccaaaagatg tgtcaccctc tctgcttctg cgatgactgt gagaaactcg tctctgggag gttgaatgat ccctcagttg tcactccatt ctccagagac gacagggggc acacccctct ccatgtggct gctgtctgtg ggcaggcatc cctcatcgac ctcctggttt ccaagggcgc catggtaaat gccacagact accatggagc cactccgctc cacctggcct gtcagaaggg ctaccagagc gtgacgctgc tgctgctgca ctacaaggcc agcgcggaag tgcaggacaa caatgggaat acgccactcc acctggcctg cacctacggc cacgaggact gtgtgaaggc tctggtttac tacgacgtgg agtcgtgcag acttgacatt ggcaatgaga aaggagacac ccctctacac attgctgccc gctggggcta ccaaggcgtc atagagacat tgctgcagaa cggagcgtcc accgagatcc agaacagact gaaggagacg cccctcaagt gtgcattaaa ctcaaagatt ctgtctgtaa tggaagccta tcacctgtcc ttcgagagga ggcagaagtc gtccgaggcc cctgtgcagt ccccgcagcg ctccgtggac tccatcagcc aagagtcctc cacttccagc ttctcctcca tgtcagccag ctcaaggcag gaggagacca agaaggacta cagagaggta gaaaaacttt tgagagcagt tgctgatgga gatctagaaa tggtgcgtta cctgttggaa tggacagagg aggacctgga ggatgcggag gacactgtca gtgcagcgga ccccgaattc tgtcacccgt tgtgccagtg ccccaagtgt gccccagctc agaagaggct ggcgaaggtt cctgccagtg ggcttggtgt gaacgtgacc agccaggacg gctcctcccc gctgcatgtc gccgccctgc acggccgggc ggacctcatc cccctcctgc tgaagcacgg ggccaacgca ggtgccagga acgcagacca agccgtcccg ctccacctgg cctgccagca gggccacttt caggtggtga agtgtctgtt agattcgaat gcaaaaccca ataagaagga cctcagtgga aacacgcccc tcatttacgc ctgctccggt ggccatcacg agcttgtggc actgctgcta cagcacgggg cctccattaa cgcttctaac aataagggca acacagcgct gcacgaggct gtgattgaaa agcacgtctt cgtggtagag ctgcttctgc tccacggagc gtcagttcag gtgctgaaca agcggcagcg cacggctgta gactgtgctg aacagaattc aaaaataatg gaattgcttc aggtggtacc aagctgtgtt gcttcattag atgatgtggc tgaaactgac cgcaaggagt atgtcactgt taagatcagg aaaaaatgga actcaaaact gtatgatcta ccagatgagc cttttacaag acagttttac tttgtccact cagctggtca gtttaaggga aagacttcaa gggagattat ggcaagagat agaagtgtcc ctaatttaac cgaaggttct ttgcatgagc cagggaggca aagtgtcaca ctgagacaga ataacctgcc agctcagagt ggatctcatg ctgctgagaa aggcaacagc gactggccag agaggcctgg actgacacag actggccctg gacacagacg gatgctgcgg agacacacgg tagaggatgc ggtcgtgtcc cagggcccgg aggctgctgg ccccctctcc actccccaag aggttagtgc ttcccggtcc Protein function: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events, in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes, the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth, the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38. Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface, the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking, the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. [The UniProt Consortium]