Mebendazole-d8

Mebendazole-d8 is intended for use as an internal standard for the quantification of mebendazole (Cay-18872) by GC- or LC-MS. Mebendazole is an inhibitor of microtubule polymerization and an anthelmintic. It reduces microtubule polymerization in a cell-free assay when used at a concentration of 10 µM. Mebendazole reduces container attachment, a measure of viability, by G. duodenalis with a half-maximal inhibition of binding (IB50) value of 190 nM. It reduces the proliferation of SK-MEL-19 and M14 melanoma cell lines (IC50s = 300 and 320 µM, respectively) and induces apoptosis and poly(ADP-ribose) polymerase (PARP) cleavage in SK-MEL-19 and M14 cells, but not melanocytes, when used at a concentration of 1 µM. It decreases oxidative stress-induced cell death in primary mouse cortical neurons in a concentration-dependent manner. In vivo, mebendazole (800 µg/animal every other day) decreases tumor volume, weight, hemoglobin levels, and vascularization in an H460 lung cancer mouse xenograft model. Mebendazole (8.8 mg/kg) eradicates S. vulgaris, S. edentates, and S. equinus worm burden in infected ponies. Formulations containing mebendazole have been used in the treatment of helminth gastrointestinal infections.Formal Name: methyl-d3 (6-(benzoyl-2,3,4,5,6-d5)-1H-benzo[d]imidazol-2-yl)carbamate. CAS Number: 1286787-80-1. Synonyms: R 17635-d8. Molecular Formula: C16H5D8N3O3. Formula Weight: 303.3. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, Methanol: Very slightly soluble. SMILES: O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])C2=CC=C(N=C(N3)NC(OC([2H])([2H])[2H])=O)C3=C2. InChi Code: InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)/i1D3,2D,3D,4D,5D,6D. InChi Key: OPXLLQIJSORQAM-JGUCLWPXSA-N.