Dapoxetine-d7 (hydrochloride)

Dapoxetine-d7 is intended for use as an internal standard for the quantification of dapoxetine by GC- or LC-MS. Dapoxetine is a selective serotonin (5-HT) reuptake inhibitor (SSRI, IC50 = 10 nM in isolated rat cerebral cortex membranes). It selectively inhibits 5-HT uptake over norepinephrine or dopamine uptake in cells expressing the human transporters (IC50s = 1.2, 202, and 1,720 nM, respectively). (S)-Dapoxetine (1 and 80 µg/animal) increases the amplitude of the pudendal motoneuron reflex discharges in a rat model of the ejaculatory expulsion reflex induced by electrical stimulation of the dorsal penis nerves. It decreases infarct volume and improves motor performance in a rat model of ischemic stroke induced by bilateral common carotid artery occlusion when administered at doses of 30 or 60 mg/kg. Dapoxetine (5 mg/kg) decreases prostate weight and levels of Tnf-alpha, inducible nitric oxide synthase (iNos), and Cox-2 in a rat model of testosterone propionate-induced benign prostatic hyperplasia (BPH). Formulations containing dapoxetine have been used in the treatment of premature ejaculation.Formal Name: N,N-dimethyl-alpha3-[2-(1-naphthalenyloxy)ethyl-d7]-benzenemethanamine, monohydrochloride. CAS Number: 2699607-47-9. Synonyms: Dapoxetine-d7, (S)-(+)-Dapoxetine-d7. Molecular Formula: C21H16D7NO . HCl. Formula Weight: 348.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: CN(C)[C@H](C1=CC=CC=C1)CCOC2=C([2H])C([2H])=C([2H])C3=C2C([2H])=C([2H])C([2H])=C3[2H].Cl. InChi Code: InChI=1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21,/h3-14,20H,15-16H2,1-2H3,1H/t20-,/m0./s1/i6D,7D,8D,9D,12D,13D,14D,. InChi Key: IHWDIQRWYNMKFM-WISGJDKSSA-N.