Cyclobenzaprine-d6 (hydrochloride)

Cyclobenzaprine-d6 is intended for use as an internal standard for the quantification of cyclobenzaprine by GC- or LC-MS. Cyclobenzaprine is a skeletal muscle relaxant. It is an antagonist of M1, M2, and M3 muscarinic acetylcholine receptors (mAChRs, Kis = 25, 60, and 6 nM, respectively), the histamine H1 receptor (IC50 = 20 nM), and serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2B, and 5-HT2C (Kis = 1,685, 330, and 56 nM, respectively). Cyclobenzaprine (1 mg/kg) prevents increases in the flexor reflex induced by the 5-HT2 receptor agonist DOI in spinalized rats. Formulations containing cyclobenzaprine have been used as muscle relaxants.Formal Name: 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-d3-1-propanamine, monohydrochloride. CAS Number: 2748492-38-6. Synonyms: MK-130-d6. Molecular Formula: C20H15D6N . HCl. Formula Weight: 317.9. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: [2H]C([2H])([2H])N(C([2H])([2H])[2H])CC/C=C1C2=C(C=CC=C2)C=CC3=C/1C=CC=C3.Cl. InChi Code: InChI=1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20,/h3-6,8-14H,7,15H2,1-2H3,1H/i1D3,2D3,. InChi Key: VXEAYBOGHINOKW-TXHXQZCNSA-N.