Unoprostone

Unoprostone is an agonist of FP receptors (EC50 = 4.12 µM), an active metabolite the ocular hypotensive agent unoprostone isopropyl ester (Cay-16681), and a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020). It is formed from unoprostone isopropyl ester by hydrolysis. Intravitreal administered unoprostone (1.2, 3.6, or 6 µg/µl) prevents constant light-induced degradation of photoreceptors in rats.Formal Name: 9alpha,11alpha-dihydroxy-13,14-dihydro-15-oxo-20a,20b-dihomoprost-5-en-1-oic acid. CAS Number: 120373-36-6. Synonyms: 13,14-dihydro-15-keto-20-ethyl Prostaglandin F2alpha, 13,14-dihydro-15-keto-20-ethyl PGF2alpha, Unoprostone (free acid). Molecular Formula: C22H38O5. Formula Weight: 382.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 25 mg/ml, DMSO: 17 mg/ml, Ethanol: 12 mg/ml, PBS (7.2): 90 µg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](CCC(CCCCCCC)=O)[C@H](O)C1. InChi Code: InChI=1S/C22H38O5/c1-2-3-4-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27/h6,9,18-21,24-25H,2-5,7-8,10-16H2,1H3,(H,26,27)/b9-6-/t18-,19-,20+,21-/m1/s1. InChi Key: TVHAZVBUYQMHBC-SNHXEXRGSA-N.