Turkesterone (hydrate)

Turkesterone is a phytoecdysteroid that has been found in A. turkestanica and has diverse biological activities. It binds to the ecdysteroid receptor (KD = 0.491 µM for the C. tentans receptor) and induces pupariation in G. mellonella, S. bullata, and D. vulpinus last instar larvae (ED50s = 10, 0.03, and 0.2 µg/larvae, respectively). Turkesterone scavenges DPPH (Cay-14805) radicals in a cell-free assay (IC50 = 140.92 µg/ml) and is cytotoxic to HeLa cervical, HepG2 hepatic, and MCF-7 breast cancer cells (IC50s = 75.2, 63.01, and 105.2 µg/ml, respectively). It decreases serum glucose levels and increases serum insulin and C-peptide levels in a rat model of diabetes induced by alloxan (Cay-9002196) when administered at a dose of 10 mg/kg. Turkesterone prevents immobilization stress-induced stomach ulcers in mice.Formal Name: (2beta,3beta,5beta,11alpha,22R)-2,3,11,14,20,22,25-heptahydroxy-cholest-7-en-6-one, hydrate. Molecular Formula: C27H44O8 . XH2O. Formula Weight: 496.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: O[C@]12C([C@@]([C@@H](C[C@@]1([C@]([C@@](C)(O)[C@H](O)CCC(C)(O)C)([H])CC2)C)O)([H])[C@@]3([C@@]4([H])C[C@H]([C@H](C3)O)O)C)=CC4=O.O. InChi Code: InChI=1S/C27H44O8.H2O/c1-23(2,33)8-7-21(32)26(5,34)20-6-9-27(35)15-11-16(28)14-10-17(29)18(30)12-24(14,3)22(15)19(31)13-25(20,27)4,/h11,14,17-22,29-35H,6-10,12-13H2,1-5H3,1H2/t14-,17+,18-,19+,20-,21+,22+,24-,25+,26+,27+,/m0./s1. InChi Key: KPDDBZPCPQHPNZ-ZSNHUFKWSA-N. Origin: Plant/Ajuga turkestanica.