TFC 007

TFC 007 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS, IC50 = 0.083 µM). It is selective for H-PGDS over lipocalin PGDS (L-PGDS) and microsomal PGE2 synthase (mPGES) at 100 µM. It is also selective for H-PGDS over COX-1, COX-2, 5-lipoxygenase (5-LO), leukotriene C4 (LTC4) synthase, and thromboxane (TX) synthase, as well as the histamine H1 and cysteinyl leukotriene 1 (CysLT1) receptors, at 10 µM. TFC 007 (30 mg/kg) inhibits antigen-induced increases in the production of PGD2 (Cay-12010) in nasal cavity lavage fluid and reduces nasal blockage in a guinea pig model of allergic rhinitis.Formal Name: N-[4-[4-(4-morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide. CAS Number: 927878-49-7. Molecular Formula: C27H29N5O4. Formula Weight: 487.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 1 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 218, 311 nm. SMILES: O=C(NC1=CC=C(N2CCC(C(N3CCOCC3)=O)CC2)C=C1)C(C=N4)=CN=C4OC5=CC=CC=C5. InChi Code: InChI=1S/C27H29N5O4/c33-25(21-18-28-27(29-19-21)36-24-4-2-1-3-5-24)30-22-6-8-23(9-7-22)31-12-10-20(11-13-31)26(34)32-14-16-35-17-15-32/h1-9,18-20H,10-17H2,(H,30,33). InChi Key: NLSSUSRERAMBTA-UHFFFAOYSA-N.