Terbutaline

Terbutaline is a short-acting beta2-adrenergic receptor (beta2-AR) agonist and an active metabolite of bambuterol (Cay-17887). It binds to beta1-, beta2-, and beta3-ARs (Ki = 31.3, 15.4, and 79.8 nM, respectively) and selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human beta2- or beta3- over beta1-ARs at concentrations 100-fold greater than the respective Ki values. Terbutaline inhibits histamine release induced by ovalbumin in isolated guinea pig lung mast cells. It also inhibits airway obstruction induced by methacholine (acetyl-beta-methylcholine, Cay-23092) or leukotriene D4 (LTD4, Cay-20310) in anesthetized guinea pigs. Formulations containing terbutaline have been used in the treatment of asthma.Formal Name: 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol. CAS Number: 23031-25-6. Molecular Formula: C12H19NO3. Formula Weight: 225.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble, Water: 100 mM. SMILES: OC1=CC(O)=CC(C(O)CNC(C)(C)C)=C1. InChi Code: InChI=1S/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8/h4-6,11,13-16H,7H2,1-3H3. InChi Key: XWTYSIMOBUGWOL-UHFFFAOYSA-N.