Tafluprost

Tafluprost is a prodrug form of the FP receptor agonist tafluprost (free acid) (Cay-10005439) and a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020). It decreases pupillary diameter in cats when applied topically at doses of 0.0001 or 0.001% v/v. Ocular administration of tafluprost (0.0005% v/v) reduces intraocular pressure in normotensive monkeys. Formulations containing tafluprost have been used in the treatment of open-angle glaucoma and ocular hypertension.Formal Name: (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid, 1-methylethyl ester. CAS Number: 209860-87-7. Synonyms: AFP-168. Molecular Formula: C25H34F2O5. Formula Weight: 452.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 269 nm. SMILES: O[C@@H](C[C@@H](O)[C@@H]1/C=C/C(F)(F)COC2=CC=CC=C2)[C@@H]1C/C=C\CCCC(OC(C)C)=O. InChi Code: InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1. InChi Key: WSNODXPBBALQOF-VEJSHDCNSA-N.