Rebamipide-d4

Rebamipide-d4 is intended for use as an internal standard for the quantification of rebamipide (Cay-17186) by GC- or LC-MS. Rebamipide is a gastroprotective agent and mucin secretagogue. It increases the levels of prostaglandin E2 (PGE2, Cay-14010) and COX-2 in rat gastric mucosa when administered at doses of 15 and 50 mg/kg per day. Rebamipide (30 and 100 mg/kg, i.p.) prevents the formation of gastric ulcers induced by absolute ethanol, sodium hydroxide, or hydrochloric acid in rats, an effect that can be blocked by the non-selective COX inhibitor indomethacin (Cay-70270). It also increases the production of mucin 16 in stratified corneal epithelial cells in vitro when used at concentrations of 10 and 100 µM. Rebamipide (1% w/v) increases the levels of mucin-like substances in rabbit conjunctiva and cornea and, in a rabbit model of dry eye disease, reduces desiccation-induced corneal damage. Formulations containing rebamipide have been used in the treatment of peptic ulcer disease and dry eye disease.Formal Name: 2-(4-chlorobenzamido-2,3,5,6-d4)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid. CAS Number: 1219409-06-9. Molecular Formula: C19H11ClD4N2O4. Formula Weight: 374.8. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)NC(C(O)=O)CC(C2=CC=CC=C2N3)=CC3=O. InChi Code: InChI=1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26)/i5D,6D,7D,8D. InChi Key: ALLWOAVDORUJLA-KDWZCNHSSA-N.