Q1-ALC-0315 (iodide)

Q1-ALC-0315 is a cationic quaternary ammonium lipid derivative of the ionizable cationic lipid ALC-0315 (Cay-34337) that has been used in the generation of lipid nanoparticles (LNPs) for use in vivo. LNPs containing Q1-ALC-0315 and ALC-0315 as a cationic lipid pair (CLP) and encapsulating mRNA encoding a luciferase reporter induce luciferase expression in the lungs and spleen in mice.Formal Name: 6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)-N-methylhexan-1-aminium, monoiodide. Molecular Formula: C49H98NO5 . I. Formula Weight: 908.2. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Soluble: >10 mg/ml. SMILES: OCCCC[N+](CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)(C)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O.[I-]. InChi Code: InChI=1S/C49H98NO5.HI/c1-6-10-14-18-20-28-38-46(36-26-16-12-8-3)48(52)54-44-34-24-22-30-40-50(5,42-32-33-43-51)41-31-23-25-35-45-55-49(53)47(37-27-17-13-9-4)39-29-21-19-15-11-7-2,/h46-47,51H,6-45H2,1-5H3,1H/q+1,/p-1. InChi Key: IHJMUQMUQJQQBU-UHFFFAOYSA-M.