PPPDA-O16B

PPPDA-O16B is a disulfide bond-containing ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for plasmid delivery in vitro and in vivo. LNPs containing PPPDA-O16B and encapsulating plasmids encoding Ras/Rap1-specific endopeptidase (RRSP) increase RRSP levels and decrease Ras levels in, and reduce the viability of, HeLa cervical cancer cells. LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart, liver, spleen, lungs, and kidneys, as well as decrease tumor volume without reducing body weight, in an HCT116 colorectal cancer mouse xenograft model.Formal Name: bis(2-(dodecyldisulfaneyl)ethyl) 3,3'-(propylazanediyl)dipropionate. Molecular Formula: C37H73NO4S4. Formula Weight: 724.2. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: Chloroform: Soluble. SMILES: CCCN(CCC(OCCSSCCCCCCCCCCCC)=O)CCC(OCCSSCCCCCCCCCCCC)=O. InChi Code: InChI=1S/C37H73NO4S4/c1-4-7-9-11-13-15-17-19-21-23-32-43-45-34-30-41-36(39)25-28-38(27-6-3)29-26-37(40)42-31-35-46-44-33-24-22-20-18-16-14-12-10-8-5-2/h4-35H2,1-3H3. InChi Key: YVPNKVLDJGNNNV-UHFFFAOYSA-N.