PAMAM Dendrimer G3.0 Amine (water solution)

PAMAM dendrimer G3.0 amine (PAMAM G3.0) is a polyamidoamine (PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vivo. It is approximately 36 Å in diameter and has 32 surface groups. It is cytotoxic to DU145 cells (IC50 = ~13.42 µM) and toxic to zebrafish embryos, inducing mortality 72 hours post-fertilization when used at a concentration of 0.2 µM. Liposomes coated with PAMAM G3.0 and encapsulating the isoquinoline alkaloid berberine (Cay-10006427) and the anthraquinone chrysophanol (Cay-19870) reduce hydrogen peroxide-induced production of reactive oxygen species (ROS) in ARPE-19 retinal epithelial cells and protect against retinal damage in a rat model of photooxidation-induced age-related macular degeneration (AMD).CAS Number: 153891-46-4. Synonyms: PAMAM G3.0, Polyamidoamine Dendrimer G3.0. Molecular Formula: [NH2(CH2)2NH2]:(G=3),dendri PAMAM(NH2)32. Formula Weight: 6908.8. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble.