PAMAM Dendrimer G1.5 Carboxylate (sodium salt) (water solution)

PAMAM dendrimer G1.5 carboxylate (PAMAM G1.5) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini. It is approximately 36.2 Å in diameter in water and has 12 surface groups. PAMAM G1.5 (10 µM) inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in Vero cells. Conjugates of PAMAM G1.5 with the active fragment of the DNA cross-linking agent oxaliplatin (Cay-13106) are cytotoxic to A2780 ovarian, MCF-7 breast, and Caco-2 colon cancer cells and BJ fibroblasts (IC50s = 0.04, 1.6, 0.3, and 1.3 µM, respectively).Formal Name: 18,21-bis[3-[[2-[bis[3-[[2-[bis(2-carboxyethyl)amino]ethyl]amino]-3-oxopropyl]amino]ethyl]amino]-3-oxopropyl]-11,28-bis[3-[[2-[bis(2-carboxyethyl)amino]ethyl]amino]-3-oxopropyl]-4,35-bis(2-carboxyethyl)-8,15,24,31-tetraoxo-4,7,11,14,18,21,25,28,32,35-decaazaoctatriacontanedioic acid, hexadecasodium salt. CAS Number: 251970-28-2. Synonyms: PAMAM G1.5 Carboxylate, Polyamidoamine Dendrimer G1.5 Carboxylate. Molecular Formula: C110H176N26O44 . 16Na. Formula Weight: 2934.6. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: O=C(CCN(CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)CCNC(CCN(CCN(CCC(NCCN(CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)=O)CCC(NCCN(CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)=O)CCC(NCCN(CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)=O)=O)NCCN(CCC([O-])=O)CCC([O-])=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C110H192N26O44.16Na/c137-83(115-33-73-127(53-13-95(149)150)54-14-96(151)152)1-41-123(42-2-84(138)116-34-74-128(55-15-97(153)154)56-16-98(155)156)69-29-111-91(145)9-49-135(50-10-92(146)112-30-70-124(43-3-85(139)117-35-75-129(57-17-99(157)158)58-18-100(159)160)44-4-86(140)118-36-76-130(59-19-101(161)162)60-20-102(163)164)81-82-136(51-11-93(147)113-31-71-125(45-5-87(141)119-37-77-131(61-21-103(165)166)62-22-104(167)168)46-6-88(142)120-38-78-132(63-23-105(169)170)64-24-106(171)172)52-12-94(148)114-32-72-126(47-7-89(143)121-39-79-133(65-25-107(173)174)66-26-108(175)176)48-8-90(144)122-40-80-134(67-27-109(177)178)68-28-110(179)180,,,,,,,,,,,,,,,,/h1-82H2,(H,111,145)(H,112,146)(H,113,147)(H,114,148)(H,115,137)(H,116,138)(H,117,139)(H,118,140)(H,119,141)(H,120,142)(H,121,143)(H,122,144)(H,149,150)(H,151,152)(H,153,154)(H,155,156)(H,157,158)(H,159,160)(H,161,162)(H,163,164)(H,165,166)(H,167,168)(H,169,170)(H,171,172)(H,173,174)(H,175,176)(H,177,178)(H,179,180),,,,,,,,,,,,,,,,/q,16*+1/p-16. InChi Key: KKDVRAVJOOYSGF-UHFFFAOYSA-A.