PAMAM Dendrimer G1.0 Amine (water solution)

PAMAM dendrimer G1.0 amine (PAMAM G1.0) is a polyamidoamine (PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vitro. It is approximately 22 Å in diameter and has 8 surface groups. Micelles composed of PAMAM G1.0 conjugated to di-n-dodecylamine and encapsulating 5-fluorouracil (5-FU, Cay-14416) increase the solubility of 5-FU and are cytotoxic to AGS gastric adenocarcinoma cells. PAMAM G1.0 conjugated to the clay mineral palygorskite (Pal-G1.0) on a PVDF membrane adsorbs the heavy metals nickel(II), cadmium(II), and copper(II) from aqueous solutions.Formal Name: N1,N24-bis(2-aminoethyl)-4,21-bis[3-[(2-aminoethyl)amino]-3-oxopropyl]-11,14-bis[3-[[2-[bis[3-[(2-aminoethyl)amino]-3-oxopropyl]amino]ethyl]amino]-3-oxopropyl]-8,17-dioxo-4,7,11,14,18,21-hexaazatetracosanediamide. CAS Number: 142986-44-5. Synonyms: PAMAM G1.0, Polyamidoamine Dendrimer G1.0. Molecular Formula: C62H128N26O12. Formula Weight: 1429.9. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: O=C(CCN(CCC(NCCN)=O)CCNC(CCN(CCN(CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)=O)NCCN. InChi Code: InChI=1S/C62H128N26O12/c63-13-21-71-51(89)1-33-83(34-2-52(90)72-22-14-64)45-29-79-59(97)9-41-87(42-10-60(98)80-30-46-84(35-3-53(91)73-23-15-65)36-4-54(92)74-24-16-66)49-50-88(43-11-61(99)81-31-47-85(37-5-55(93)75-25-17-67)38-6-56(94)76-26-18-68)44-12-62(100)82-32-48-86(39-7-57(95)77-27-19-69)40-8-58(96)78-28-20-70/h1-50,63-70H2,(H,71,89)(H,72,90)(H,73,91)(H,74,92)(H,75,93)(H,76,94)(H,77,95)(H,78,96)(H,79,97)(H,80,98)(H,81,99)(H,82,100). InChi Key: QVWIZHOFYGKROL-UHFFFAOYSA-N.