Norbixin (hydrate)

Norbixin is a carotenoid that has been found in B. orellana and has diverse biological activities. It binds to peroxisome proliferator-activated receptor gamma (PPARgamma) in a cell-free assay (Ki = 1.15 µM). Norbixin (47.7 mg/kg) attenuates hyperglycemia, hyperinsulinemia, and insulin resistance, as well as decreases serum lipid levels and cardiac levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) in a rat model of cardio-metabolic syndrome. It decreases serum levels of oxidized LDL and aortic protein oxidation, as well as reduces atherosclerotic area, in a rabbit model of cholesterol-induced atherosclerosis. Norbixin (0.1 and 1 mg/kg per day) reduces mercury-induced DNA damage in isolated rat hepatocytes and leukocytes. It also prevents photoreceptor degeneration in an Abca4-/- Rdh8-/- mouse model of age-related macular degeneration (AMD).Formal Name: 4,8,13,17-tetramethyl-2E,4E,6E,8E,10E,12E,14E,16E,18E-eicosanonaenedioic acid, hydrate. Molecular Formula: C24H28O4 . XH2O. Formula Weight: 380.5. Purity: >70%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, Methanol: Slightly soluble, THF: Slightly soluble. SMILES: OC(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(O)=O)=O. InChi Code: InChI=1S/C24H28O4/c1-19(11-7-13-21(3)15-17-23(25)26)9-5-6-10-20(2)12-8-14-22(4)16-18-24(27)28/h5-18H,1-4H3,(H,25,26)(H,27,28)/b6-5+,11-7+,12-8+,17-15+,18-16+,19-9+,20-10+,21-13+,22-14+. InChi Key: ZVKOASAVGLETCT-UOGKPENDSA-N. Origin: Synthetic.