Nabumetone

Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 6-methoxy naphthalene acetic acid (Cay-70620). Nabumetone (5-45 mg/kg) reduces carrageenan-induced edema in rats, as well as UV-induced erythema in guinea pigs (ED50 = 11 mg/kg). It reduces phenyl-p-quinone-induced writhing in mice (ED50 = 152 mg/kg). Nabumetone (50, 100, and 200 mg/kg) reduces endotoxin-induced pyresis in rabbits.Formal Name: 4-(6-methoxy-2-naphthalenyl)-2-butanone. CAS Number: 42924-53-8. Synonyms: BRL 14777. Molecular Formula: C15H16O2. Formula Weight: 228.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.09 mg/ml, Ethanol: 20 mg/ml. lambdamax: 230 nm. SMILES: COC1=CC=C2C(C=CC(CCC(C)=O)=C2)=C1. InChi Code: InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3. InChi Key: BLXXJMDCKKHMKV-UHFFFAOYSA-N.