N-Palmitoyl Glycine

The acyl amides are a family of endogenous lipids that act as potent modulators of pain and inflammation. The best characterized members of this family are the arachidonoyl amides, which includes N-arachidonoyl ethanolamide (AEA, anandamide). N-palmitoyl glycine (PalGly) contains an 18-carbon saturated fatty acid that is amide-linked to glycine and is structurally similar to the phospholipid-derived N-acyl ethanolamines. Endogenously produced in rat skin and spinal cord, PalGly is present in 100-fold greater amounts in skin and 3-fold greater in brain compared to AEA. Injection of 0.43 µg PalGly in rat hindpaw inhibits heat-induced firing of nociceptive neurons in rat dorsal horn. PalGly treatment induces transient calcium influx in native dorsal root ganglion (DRG) cells and in the PTX-sensitive, DRG-like cell line F-11 (EC50 = 5.5 µM).Formal Name: N-(1-oxohexadecyl)-glycine. CAS Number: 2441-41-0. Synonyms: N-Hexadecanoyl-Glycine, PalGly. Molecular Formula: C18H35NO3. Formula Weight: 313.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: Soluble. SMILES: CCCCCCCCCCCCCCCC(NCC(O)=O)=O. InChi Code: InChI=1S/C18H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(20)19-16-18(21)22/h2-16H2,1H3,(H,19,20)(H,21,22). InChi Key: KVTFEOAKFFQCCX-UHFFFAOYSA-N.