Meglutol

Meglutol is an HMG-CoA reductase inhibitor (IC50 = 4 nM) and antimetabolite of mevalonic acid. Dietary administration of meglutol (10, 20, and 30 mg/kg per day) reduces serum total cholesterol levels in normal rats, as well as reduces them in high-cholesterol fed and hypercholesterolemic rats when administered in the drinking water at a dose of 50 mg/kg per day. It also reduces serum levels of cholesterol, triglycerides, phospholipids, and free fatty acids, as well as the severity of aortic atherosclerotic lesions, in a rabbit model of atherosclerosis induced by a high-cholesterol diet when administered at a dose of 25 mg/animal per day. Intracerebroventricular administration of meglutol (0.5 µmol/g) induces lipid peroxidation and decreases the activity of glutathione peroxidase in the cerebral cortex of one-day old rat pups. Meglutol accumulates in the tissues and fluids of patients with HMG-CoA lyase deficiency, a disorder characterized by metabolic acidosis, hypoglycemia, and lethargy.Formal Name: 3-hydroxy-3-methyl-pentanedioic acid. CAS Number: 503-49-1. Synonyms: CB 337, Dicrotalic Acid, 3-hydroxy 3-methyl Glutaric Acid, HMG, 3-methyl-3-Hydroxyglutaric Acid, NSC 361411, Medroglutaric Acid, 3-hydroxy-3-Methylglutaric Acid. Molecular Formula: C6H10O5. Formula Weight: 1499.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(CC(C)(CC(O)=O)O)OO=C(CC(C)(CC(O)=O)O)O. InChi Code: InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10). InChi Key: NPOAOTPXWNWTSH-UHFFFAOYSA-N.