Malotilate

Malotilate is a hepatoprotective agent. It inhibits A23187-induced metabolism of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) to the 5-lipoxygenase (5-LO) metabolites leukotriene B4 (LTB4, Cay-20110) and 5-HETE in macrophages isolated from the ascitic fluid of patients with alcoholic liver cirrhosis. Malotilate (50 mg/kg) prevents increases in plasma glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) activities in a rat model of carbon tetrachloride-induced liver injury. It reduces hepatic deposition of type III procollagen, type IV collagen, laminin, and fibronectin in a rat model of dimethylnitrosamine-induced hepatic fibrosis when administered at a dose of 100 mg/kg.Formal Name: 2-(1,3-dithiol-2-ylidene)-propanedioic acid, 1,3-bis(1-methylethyl) ester. CAS Number: 59937-28-9. Synonyms: NKK-105. Molecular Formula: C12H16O4S2. Formula Weight: 288.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20mg/mL, DMSO: 10mg/mL, Ethanol: 25mg/mL, Ethanol:PBS (pH 7.2) (1:3): 0.25mg/mL. lambdamax: 223, 362 nm. SMILES: CC(C)OC(/C(C(OC(C)C)=O)=C1SC=CS\1)=O. InChi Code: InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3. InChi Key: YPIQVCUJEKAZCP-UHFFFAOYSA-N.