KRP 297

KRP 927 is a thiazolidinedione dual agonist of PPARalpha and PPARgamma (EC50s = 149 and 83 nM, respectively, in transactivation assays). It decreases hyperglycemia and hyperinsulinemia in ob/ob mice in a dose-dependent manner. KRP 927 (10 or 30 mg/kg) reduces serum total cholesterol and triglyceride levels in hamsters.Formal Name: 5-[(2,4-dioxo-5-thiazolidinyl)methyl]-2-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]-benzamide. CAS Number: 213252-19-8. Synonyms: MK-767. Molecular Formula: C20H17F3N2O4S. Formula Weight: 438.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mg/ml. SMILES: COC(C(C(NCC1=CC=C(C(F)(F)F)C=C1)=O)=C2)=CC=C2CC3C(NC(S3)=O)=O. InChi Code: InChI=1S/C20H17F3N2O4S/c1-29-15-7-4-12(9-16-18(27)25-19(28)30-16)8-14(15)17(26)24-10-11-2-5-13(6-3-11)20(21,22)23/h2-8,16H,9-10H2,1H3,(H,24,26)(H,25,27,28). InChi Key: NFFXEUUOMTXWCX-UHFFFAOYSA-N.