Kdo2-Lipid A (ready-to-use)

Defined substructure of the Re mutant of lipopolysaccharide (LPS), Endotoxin activity equal to Re LPS, Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4), Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA, Facilitates the structural analysis of its complexes with signaling receptors, such as TLR4/MD2 and CD14, Kdo2-Lipid A was used in a recent animal atherosclerosis model, Induces sphingolipid biosynthesis, which is essential for induction of autophagy.