Inotilone

Inotilone is a cyclooxygenase (COX) inhibitor found in mushrooms of Phellinus and Inonotus sps. that inhibits COX-2 over COX-1 with IC50 values of 0.03 and 0.36 µM, respectively. It is a poor inhibitor of hydroxysteroid dehydrogenase and xanthine oxidase (IC50s = 50.4 and 9.1 µM, respectively). Inotilone demonstrates anti-inflammatory, antiviral, and antioxidant effects in various experimental models.Formal Name: (2Z)-2-[(3,4-dihydroxyphenyl)methylene]-5-methyl-3(2H)-furanone. CAS Number: 906366-79-8. Molecular Formula: C12H10O4. Formula Weight: 218.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 246, 265, 386 nm. SMILES: OC1=CC=C(/C=C2OC(C)=CC\2=O)C=C1O. InChi Code: InChI=1S/C12H10O4/c1-7-4-11(15)12(16-7)6-8-2-3-9(13)10(14)5-8/h2-6,13-14H,1H3/b12-6-. InChi Key: NLZQGBCUKNUDED-SDQBBNPISA-N.