Halobetasol Propionate

Halobetasol propionate is a synthetic glucocorticoid. It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 µg/animal) and by oxazolone in mice (ED50 = 0.8 µg/animal). Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 µg/ml and 0.5 µg/ear) and mice (ED50s = 1.2 and <0.32 µg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis.Formal Name: 21-chloro-6alpha,9-difluoro-11beta-hydroxy-16beta-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione. CAS Number: 66852-54-8. Synonyms: BMY 30056, CGP 14458. Molecular Formula: C25H31ClF2O5. Formula Weight: 485.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@H](C)[C@@]4(C(CCl)=O)OC(CC)=O)=C1. InChi Code: InChI=1S/C25H31ClF2O5/c1-5-21(32)33-25(20(31)12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15-,16-,18-,19-,22-,23-,24-,25-/m0/s1. InChi Key: BDSYKGHYMJNPAB-LICBFIPMSA-N.