Halcinonide

Halcinonide is a synthetic glucocorticoid with anti-inflammatory properties. In a rabbit model of edema, topical application of halcinonide (0.1% w/w) decreases edema by 55% in a reversed passive Arthus skin test (RPA). Halcinonide (0.1% w/w) inhibits croton oil-induced ear edema by 70.1% and homologous passive cutaneous anaphylaxis (PCA) by 88.0% in rats dosed three hours prior to induction of inflammation. Application of halcinonide (0.1% w/w) to the abraded surface of cecum in rats inhibits leukocyte adhesion (43.3% incidence versus 100% for controls) and lowers the total number of intraperitoneal leukocytes from 270 million to 121 million 3 days post surgery. It also acts as an agonist at the smoothened (Smo) receptor with an EC50 value of 1,100 nM. Formulations containing halcinonide have been used to treat inflammatory and corticosteroid-responsive dermatoses.Formal Name: 21-chloro-9-fluoro-11beta-hydroxy-16alpha,17-[(1-methylethylidene)bis(oxy)]-pregn-4-ene-3,20-dione. CAS Number: 3093-35-4. Synonyms: SQ 18,566. Molecular Formula: C24H32ClFO5. Formula Weight: 455.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble. SMILES: O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@@]4(C(CCl)=O)OC(C)(C)O5)=C1. InChi Code: InChI=1S/C24H32ClFO5/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,26)17(28)11-22(16,4)24(19,31-20)18(29)12-25/h9,15-17,19,28H,5-8,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1. InChi Key: MUQNGPZZQDCDFT-JNQJZLCISA-N.