Glabrol

Glabrol
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay37367-1 1 mg -

6 - 10 Werktage*

162,00 €
Cay37367-5 5 mg -

6 - 10 Werktage*

724,00 €
Cay37367-10 10 mg -

6 - 10 Werktage*

1.286,00 €
 
Glabrol is a flavonoid that has been found in G. glabra and has diverse biological activities. It... mehr
Produktinformationen "Glabrol"
Glabrol is a flavonoid that has been found in G. glabra and has diverse biological activities. It inhibits neuraminidase (NA) activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC50s = 0.51 and 14.1 µM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B), acyl-coenzyme A:cholesterol acyltransferase (ACAT), and diacylglycerol acyltransferase (DGAT, IC50s = 0.31, 24.6, and 8 µM, respectively). Glabrol is cytotoxic to MCF-7 breast, SW480 colon, and HepG2 liver cancer cells (IC50s = 7.62, 5.15, and 2.83 µM, respectively) and is active against methicillin-resistant S. aureus (MRSA, MIC50 = 2 µg/ml). It binds to the benzodiazepine receptor (Ki = 1.63 µM) and increases pentobarbital-induced sleep duration in mice when administered at a dose of 50 mg/kg, an effect that can be reversed by the GABAA receptor antagonist flumazenil (Cay-14252).Formal Name: (2S)-2,3-dihydro-7-hydroxy-2-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one. CAS Number: 59870-65-4. Molecular Formula: C25H28O4. Formula Weight: 392.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 218, 286 nm. SMILES: C/C(C)=C\CC1=C2C(C(C[C@](C3=CC(C/C=C(C)\C)=C(C=C3)O)([H])O2)=O)=CC=C1O. InChi Code: InChI=1S/C25H28O4/c1-15(2)5-7-17-13-18(8-11-21(17)26)24-14-23(28)20-10-12-22(27)19(25(20)29-24)9-6-16(3)4/h5-6,8,10-13,24,26-27H,7,9,14H2,1-4H3/t24-/m0/s1. InChi Key: CUFAXDWQDQQKFF-DEOSSOPVSA-N. Origin: Plant/Glycyrrhiza uralensis Fisch.
Schlagworte: (2S)-2,3-dihydro-7-hydroxy-2-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
Hersteller: Cayman Chemical
Hersteller-Nr: 37367

Eigenschaften

Anwendung: Bioactive flavonoid
MW: 392.5 D
Formel: C25H28O4
Reinheit: >98%
Format: Solid

Datenbank Information

CAS : 59870-65-4| Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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