Fingolimod

Fingolimod is an immune modulator, a prodrug form of the sphingosine-1-phosphate (S1P) receptor agonist FTY720 phosphate (Cay-10008639), and a derivative of myriocin (Cay-63150). It selectively inhibits calcium-dependent cytosolic phospholipase A2 (cPLA2) over calcium-independent PLA2 (iPLA2) and secretory PLA2 (sPLA2) (Type V) when used at a concentration of 800 pmol and inhibits S1P lyase when used at concentrations ranging from 0.3 to 30 µM. Fingolimod (1 mg/kg) decreases the number of circulating lymphocytes in mice. It increases skin allograft survival in rats when administered at doses ranging from 0.3 to 3 mg/kg. Fingolimod (0.3 mg/kg) prevents disease development in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by immunization with an emulsion of bovine spinal cord in complete Freund's adjuvant. Formulations containing fingolimod have been used in the treatment of multiple sclerosis.Formal Name: 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol. CAS Number: 162359-55-9. Synonyms: FTY720. Molecular Formula: C19H33NO2. Formula Weight: 307.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 218 nm. SMILES: OCC(N)(CO)CCC1=CC=C(CCCCCCCC)C=C1. InChi Code: InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3. InChi Key: KKGQTZUTZRNORY-UHFFFAOYSA-N.