Estramustine Phosphate (sodium salt)

Estramustine Phosphate (sodium salt)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay23126-10 10 mg -

6 - 10 Werktage*

40,00 €
Cay23126-50 50 mg -

6 - 10 Werktage*

149,00 €
Cay23126-100 100 mg -

6 - 10 Werktage*

219,00 €
Cay23126-250 250 mg -

6 - 10 Werktage*

497,00 €
 
Estramustine phosphate is a derivative of estradiol (Cay-20776, Cay-10006315) that contains a... mehr
Produktinformationen "Estramustine Phosphate (sodium salt)"
Estramustine phosphate is a derivative of estradiol (Cay-20776, Cay-10006315) that contains a nor-nitrogen mustard group. Estramustine phosphate destabilizes microtubules by binding to microtubule-associated proteins (MAPs) with Kd values of 10 and 15 µM for MAP-1 and MAP-2, respectively. Estramustine induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells and induces apoptosis in U87MG human malignant glioma cells. The metabolites of estramustine phosphate have anti-androgenic effects. Formulations containing estramustine phosphate are used in the palliative treatment of prostate cancer.Formal Name: estra-1,3,5(10)-triene-3,17-diol (17beta)-3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt. CAS Number: 52205-73-9. Synonyms: Ro 21-8837/001. Molecular Formula: C23H30Cl2NO6P . 2Na. Formula Weight: 564.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25 mg/ml, DMSO: 0.25 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 204, 269 nm. SMILES: [O-]P(O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(OC(N(CCCl)CCCl)=O)=CC=C4[C@@]3([H])CC[C@@]21C)([O-])=O.[Na+].[Na+]. InChi Code: InChI=1S/C23H32Cl2NO6P.2Na/c1-23-9-8-18-17-5-3-16(31-22(27)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)32-33(28,29)30,,/h3,5,14,18-21H,2,4,6-13H2,1H3,(H2,28,29,30),,/q,2*+1/p-2/t18-,19-,20+,21+,23+,,/m1../s1. InChi Key: IIUMCNJTGSMNRO-VVSKJQCTSA-L.
Schlagworte: Ro 21-8837/001, estra-1,3,5(10)-triene-3,17-diol (17beta)-3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt
Hersteller: Cayman Chemical
Hersteller-Nr: 23126

Eigenschaften

Anwendung: Microtubule destabilizer
MW: 564.3 D
Formel: C23H30Cl2NO6P . 2Na
Reinheit: >95%
Format: Crystalline Solid

Datenbank Information

CAS : 52205-73-9| Passende Produkte
KEGG ID : K07375 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H351, H361
P-Sätze: P201, P202, P280, P308+P313, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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