Disogluside

Disogluside is a steroidal saponin that has been found in T. tschonoskii and has diverse biological activities. It is an inhibitor of UDP-glucuronosyltransferase (UGT) isoform UGT1A4 (IC50 = 10.5 µM). Disogluside is cytotoxic to K562 chronic myeloid leukemia (CML) cells (IC50 = ~7.5 µM). It improves neurological function and decreases neuronal damage in a rat model of spinal cord injury when administered at a dose of 100 mg/kg. Disogluside (50 mg/kg) decreases serum levels of glucose, insulin, and triglycerides in diabetic db/db mice. It reduces serum malondialdehyde (MDA) levels and stomach myeloperoxidase (MPO) activity in a mouse model of ethanol-induced gastric ulcers.Formal Name: (3beta,25R)-spirost-5-en-3-yl beta-D-glucopyranoside. CAS Number: 14144-06-0. Synonyms: Diosgenin 3-O-beta-D-Glucopyranoside, Diosgenin Glucoside, Diosgenyl beta-D-Glucopyranoside. Molecular Formula: C33H52O8. Formula Weight: 576.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml. SMILES: C[C@@]12[C@]3([H])[C@@](C[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)=CC4)C)([H])CC2)([H])O[C@]7(CC[C@H](CO7)C)[C@H]3C. InChi Code: InChI=1S/C33H52O8/c1-17-7-12-33(38-16-17)18(2)26-24(41-33)14-23-21-6-5-19-13-20(8-10-31(19,3)22(21)9-11-32(23,26)4)39-30-29(37)28(36)27(35)25(15-34)40-30/h5,17-18,20-30,34-37H,6-16H2,1-4H3/t17-,18+,20+,21-,22+,23+,24+,25-,26+,27-,28+,29-,30-,31+,32+,33-/m1/s1. InChi Key: WXMARHKAXWRNDM-GAMIEDRGSA-N. Origin: Plant/Trillium tschonoskii Maxim Root.