Decanoic Acid (sodium salt)

Decanoic acid is a medium-chain saturated fatty acid. It is a non-competitive antagonist at AMPA receptors that selectively reduces glutamate-induced currents in Xenopus oocytes expressing GluA2 and GluA3 subunit-containing AMPA receptors (IC50 = 0.52 mM) over those expressing GluA1 (IC50 = 2.09 mM) or GluA1 and GluA2 subunits (IC50 = 1.16 mM). It inhibits epileptiform activity induced by pentylenetetrazole (Cay-18682) or low magnesium in rat hippocampal slices. Decanoic acid (1 mM) induces contractions in isolated guinea pig duodenum, an effect that can be blocked by the muscarinic acetylcholine receptor antagonist hyoscine, voltage-gated sodium channel inhibitor tetrodotoxin (Cay-14964, Cay-14963), or M2 muscarinic acetylcholine receptor antagonist hexamethonium (Cay-25505). It increases the escape threshold in an orofacial mechanical stimulation test in rats when administered at a topical dose of 30% in ointment form, indicating analgesic activity. This effect can be blocked by the muscarinic acetylcholine receptor antagonist methoctramine (Cay-24317). Plasma levels of decanoic acid are increased in patients with colorectal cancer when compared to patients with breast cancer or ulcerative colitis or without cancer.Formal Name: decanoic acid, monosodium salt. CAS Number: 1002-62-6. Synonyms: C10:0, Capric Acid, Decylic Acid, FA 10:0. Molecular Formula: C10H19O2 . Na. Formula Weight: 194.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: [O-]C(CCCCCCCCC)=O.[Na+]. InChi Code: InChI=1S/C10H20O2.Na/c1-2-3-4-5-6-7-8-9-10(11)12,/h2-9H2,1H3,(H,11,12),/q,+1/p-1. InChi Key: FIWQZURFGYXCEO-UHFFFAOYSA-M. Side Chain Carbon Sum: 10:0.