CVT-12012

CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD, IC50 = 6.1 nM in HepG2 cells). It dose-dependently reduces levels of the SCD desaturation products palmitoleic acid (Cay-10009871) and vaccenic acid in the plasma and liver of rats fed a high-sucrose diet. CVT-12012 (20 mg/kg) also reduces hepatic triglyceride levels in sucrose-fed rats.Formal Name: 2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]-acetamide. CAS Number: 1018675-35-8. Molecular Formula: C21H21F3N4O3. Formula Weight: 434.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml, Ethanol: 1 mg/ml. lambdamax: 228, 379 nm. SMILES: CC(C(N1CCNC(CO)=O)=O)=NC(C1=C2)=CC=C2NCC3=CC(C(F)(F)F)=CC=C3. InChi Code: InChI=1S/C21H21F3N4O3/c1-13-20(31)28(8-7-25-19(30)12-29)18-10-16(5-6-17(18)27-13)26-11-14-3-2-4-15(9-14)21(22,23)24/h2-6,9-10,26,29H,7-8,11-12H2,1H3,(H,25,30). InChi Key: HRAQDVZJYIAWOV-UHFFFAOYSA-N.