(+)-Cloprostenol isopropyl ester

(+)-Cloprostenol is a synthetic analog of prostaglandin F2alpha (PGF2alpha). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. It is 200 times more potent than PGF2alpha in terminating pregnancy when given subcutaneously at a daily dose of 0.125 µg/kg in rats and hamsters, without the side effects associated with PGF2alpha. (+)-Cloprostenol was also shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3 x 10-12 M. (+)-Cloprostenol isopropyl ester is a more lipid soluble form of cloprostenol.Formal Name: (+)-9alpha,11alpha,15R-trihydroxy-16-(3-chlorophenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester. CAS Number: 157283-66-4. Synonyms: (+)-5-cis Cloprostenol isopropyl ester, (+)-16-m-chlorophenoxy tetranor Prostaglandin F2alpha isopropyl ester. Molecular Formula: C25H35ClO6. Formula Weight: 467.0. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. SMILES: CC(C)OC(CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)COC2=CC=CC(Cl)=C2)[C@H](O)C[C@@H]1O)=O. InChi Code: InChI=1S/C25H35ClO6/c1-17(2)32-25(30)11-6-4-3-5-10-21-22(24(29)15-23(21)28)13-12-19(27)16-31-20-9-7-8-18(26)14-20/h3,5,7-9,12-14,17,19,21-24,27-29H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1. InChi Key: OCNSAYQJDKJOLH-AHTXBMBWSA-N.