Cirsimaritin

Cirsimaritin is a flavone that has been found in D. kotschyi and has diverse biological activities. It binds to rat adenosine A1, rat A2A, and human A3 receptors (Kis = 1.2, 3, and 1.72 µM, respectively, in radioligand binding assays), as well as inhibits dipeptidyl peptidase 4 (DPP-4, IC50 = 0.43 µM). Cirsimaritin is active against the chloroquine-sensitive NF54 strain of P. falciparum (IC50 = 16.9 µM). It inhibits the proliferation of AGS, HT-29, Saos-2, and WEHI 164 cells (IC50s = 14.4, 13.1, 38.5, and 40.7 µM, respectively). Cirsimaritin (10 mg/kg) increases the number of entries into, and percentage of time spent in, the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.Formal Name: 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one. CAS Number: 6601-62-3. Synonyms: 5,4'-Dihydroxy-6,7-dimethoxyflavone. Molecular Formula: C17H14O6. Formula Weight: 314.3. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mM. SMILES: O=C1C=C(C2=CC=C(C=C2)O)OC3=CC(OC)=C(C(O)=C13)OC. InChi Code: InChI=1S/C17H14O6/c1-21-14-8-13-15(16(20)17(14)22-2)11(19)7-12(23-13)9-3-5-10(18)6-4-9/h3-8,18,20H,1-2H3. InChi Key: ZIIAJIWLQUVGHB-UHFFFAOYSA-N. Origin: Plant/Unidentified sp..