C9-200

C9-200 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs). LNPs containing C9-200 and encapsulating mRNA encoding erythropoietin (EPO) increase serum EPO levels in mice. LNPs containing C9-200 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA) targeting transthyretin (TTR) induce 3-fold higher hepatic insertion and deletion (indel) formation than LNPs containing C12-200 (Cay-36699) and encapsulating mRNA encoding Cas9 in mice.Formal Name: 1,1'-((2-(4-(2-((2-(bis(2-hydroxynonyl)amino)ethyl)(2-hydroxynonyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(nonan-2-ol). Molecular Formula: C55H115N5O5. Formula Weight: 926.5. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: OC(CCCCCCC)CN(CCN(CC(CCCCCCC)O)CC(CCCCCCC)O)CCN1CCN(CCN(CC(CCCCCCC)O)CC(CCCCCCC)O)CC1. InChi Code: InChI=1S/C55H115N5O5/c1-6-11-16-21-26-31-51(61)46-58(43-45-60(49-54(64)34-29-24-19-14-9-4)50-55(65)35-30-25-20-15-10-5)42-40-56-36-38-57(39-37-56)41-44-59(47-52(62)32-27-22-17-12-7-2)48-53(63)33-28-23-18-13-8-3/h51-55,61-65H,6-50H2,1-5H3. InChi Key: RLGMOTIOGPJNJN-UHFFFAOYSA-N.