C14-A1

C14-A1 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs). LNPs containing C14-A1 and encapsulating mRNA expressing forkhead box protein P3 (FOXP3) increase FOXP3 levels in primary human T cells. LNPs containing C14-A1 and encapsulating mRNA expressing FOXP3 also reduce the proliferation of primary human CD4+/CD8+ T cells, as well increase TGF-beta1 and decrease IL-10 secretion from CD4+/CD8+ T cells.Formal Name: 1,1'-((5-(4-(2-((5-(bis(2-hydroxytetradecyl)amino)pentyl)(2-hydroxytetradecyl)amino)ethyl)piperazin-1-yl)pentyl)azanediyl)bis(tetradecan-2-ol). Molecular Formula: C86H177N5O5. Formula Weight: 1361.4. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Methanol: Soluble. SMILES: OC(CN(CC(O)CCCCCCCCCCCC)CCCCCN(CC(CCCCCCCCCCCC)O)CCN1CCN(CCCCCN(CC(O)CCCCCCCCCCCC)CC(CCCCCCCCCCCC)O)CC1)CCCCCCCCCCCC. InChi Code: InChI=1S/C86H177N5O5/c1-6-11-16-21-26-31-36-41-46-53-62-82(92)77-89(68-59-52-61-70-91(80-85(95)65-56-49-44-39-34-29-24-19-14-9-4)81-86(96)66-57-50-45-40-35-30-25-20-15-10-5)76-75-88-73-71-87(72-74-88)67-58-51-60-69-90(78-83(93)63-54-47-42-37-32-27-22-17-12-7-2)79-84(94)64-55-48-43-38-33-28-23-18-13-8-3/h82-86,92-96H,6-81H2,1-5H3. InChi Key: CZFJIWVQJQUJCJ-UHFFFAOYSA-N.