C12-200

C12-200 is a branched-chain ionizable cationic lipidoid. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA, siRNA, or self-amplifying RNA (saRNA). Administration of human erythropoietin (EPO) mRNA or factor VII siRNA in C12-200-containing LNPs increases serum EPO levels and reduces factor VII serum levels, respectively, in mice.Formal Name: 1,1'-[[2-[4-[2-[[2-[bis(2-hydroxydodecyl)amino]ethyl](2-hydroxydodecyl)amino]ethyl]-1-piperazinyl]ethyl]imino]bis-2-dodecanol. CAS Number: 1220890-25-4. Molecular Formula: C70H145N5O5. Formula Weight: 1136.9. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Soluble. SMILES: OC(CCCCCCCCCC)CN(CCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)CCN1CCN(CCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)CC1. InChi Code: InChI=1S/C70H145N5O5/c1-6-11-16-21-26-31-36-41-46-66(76)61-73(58-60-75(64-69(79)49-44-39-34-29-24-19-14-9-4)65-70(80)50-45-40-35-30-25-20-15-10-5)57-55-71-51-53-72(54-52-71)56-59-74(62-67(77)47-42-37-32-27-22-17-12-7-2)63-68(78)48-43-38-33-28-23-18-13-8-3/h66-70,76-80H,6-65H2,1-5H3. InChi Key: RVHYPUORVDKRTM-UHFFFAOYSA-N.