BPR0912

BPR0912 is a cannabinoid 1 (CB1) receptor inverse agonist (IC50 = 8.5 nM for the human receptor). It is selective for CB1 over CB2 receptors (IC50 = 604.9 nM for the human receptor). In vivo, BPR0912 (10 mg/kg per day) inhibits diet-induced increases in body weight, epididymal and inguinal fat pad mass, and serum levels of insulin and triglycerides, as well as hepatic triglyceride levels, in a mouse model of high-fat diet-induced obesity. It also increases the levels of mitochondrial uncoupling protein 1 (Ucp1) in brown adipose tissue from, as well as induces thermogenesis in, mice in the same mouse model.Formal Name: 1-(2,4-dichlorophenyl)-4-ethyl-N-1-piperidinyl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide. CAS Number: 1253641-65-4. Synonyms: TM38837. Molecular Formula: C30H25Cl2F3N4OS. Formula Weight: 617.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: CCC1=C(C2=CC=C(C#CC3=CC=C(C(F)(F)F)C=C3)S2)N(C4=CC=C(Cl)C=C4Cl)N=C1C(NN5CCCCC5)=O. InChi Code: InChI=1S/C30H25Cl2F3N4OS/c1-2-23-27(29(40)37-38-16-4-3-5-17-38)36-39(25-14-11-21(31)18-24(25)32)28(23)26-15-13-22(41-26)12-8-19-6-9-20(10-7-19)30(33,34)35/h6-7,9-11,13-15,18H,2-5,16-17H2,1H3,(H,37,40). InChi Key: VQOCBFYUDSBDCZ-UHFFFAOYSA-N.