AZD 1981

AZD 1981 is a DP2/CRTH2 receptor antagonist (IC50 = 3.98 nM). It is selective for DP2 over a panel of receptors, ion channels, transporters, and enzymes, including DP1, COX-1, and COX-2, at 10 µM. AZD 1981 (3-100 nM) inhibits increases in the expression of CD11b, a cell adhesion molecule, induced by 13,14-dihydro-15-keto-prostaglandin D2 (13,14-dihydro-15-keto-PGD2, Cay-12610) in isolated human eosinophils. It also inhibits 13,14-dihydro-15-keto-PGD2-induced chemotaxis of isolated human eosinophils and T cells in a concentration-dependent manner.Formal Name: 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid. CAS Number: 802904-66-1. Molecular Formula: C19H17ClN2O3S. Formula Weight: 388.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 15 mg/ml, DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml. lambdamax: 223, 291 nm. SMILES: CC(NC1=C(C(SC2=CC=C(Cl)C=C2)=C(C)N3CC(O)=O)C3=CC=C1)=O. InChi Code: InChI=1S/C19H17ClN2O3S/c1-11-19(26-14-8-6-13(20)7-9-14)18-15(21-12(2)23)4-3-5-16(18)22(11)10-17(24)25/h3-9H,10H2,1-2H3,(H,21,23)(H,24,25). InChi Key: JWYIGNODXSRKGP-UHFFFAOYSA-N.